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Harsha Nagar 1 Article
Basic science and research
Role of Mitochondrial Oxidative Stress in Sepsis
Harsha Nagar, Shuyu Piao, Cuk-Seong Kim
Acute Crit Care. 2018;33(2):65-72.   Published online May 31, 2018
DOI: https://doi.org/10.4266/acc.2018.00157
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AbstractAbstract PDF
Mitochondria are considered the power house of the cell and are an essential part of the cellular infrastructure, serving as the primary site for adenosine triphosphate production via oxidative phosphorylation. These organelles also release reactive oxygen species (ROS), which are normal byproducts of metabolism at physiological levels; however, overproduction of ROS under pathophysiological conditions is considered part of a disease process, as in sepsis. The inflammatory response inherent in sepsis initiates changes in normal mitochondrial functions that may result in organ damage. There is a complex system of interacting antioxidant defenses that normally function to combat oxidative stress and prevent damage to the mitochondria. It is widely accepted that oxidative stress-mediated injury plays an important role in the development of organ failure; however, conclusive evidence of any beneficial effect of systemic antioxidant supplementation in patients with sepsis and organ dysfunction is lacking. Nevertheless, it has been suggested that antioxidant therapy delivered specifically to the mitochondria may be useful.

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  • Oxidative Stress in Sepsis: A Focus on Cardiac Pathology
    Giuseppe Bertozzi, Michela Ferrara, Aldo Di Fazio, Aniello Maiese, Giuseppe Delogu, Nicola Di Fazio, Vittoria Tortorella, Raffaele La Russa, Vittorio Fineschi
    International Journal of Molecular Sciences.2024; 25(5): 2912.     CrossRef
  • Proteome characterization of liver–kidney comorbidity after microbial sepsis
    Yuan Gui, Yanbao Yu, Wenjia Wang, Yuanyuan Wang, Hanyue Lu, Sarah Mozdzierz, Kirollos Eskander, Yi‐Han Lin, Hanwen Li, Xiao‐Jun Tian, Silvia Liu, Dong Zhou
    The FASEB Journal.2024;[Epub]     CrossRef
  • Macrophages-regulating nanomedicines for sepsis therapy
    Jiali Deng, Rui Wang, Shu Huang, Jinsong Ding, Wenhu Zhou
    Chinese Chemical Letters.2023; 34(3): 107588.     CrossRef
  • Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study
    Hilal Üstündağ, Özlem Demir, Betül Çiçek, Mehmet Tahir Huyut, Neslihan Yüce, Taha Tavacı
    Clinical and Experimental Pharmacology and Physiology.2023; 50(8): 634.     CrossRef
  • Sepsis-induced mitochondrial dysfunction: A narrative review
    Wagner Nedel, Caroline Deutschendorf, Luis Valmor Cruz Portela
    World Journal of Critical Care Medicine.2023; 12(3): 139.     CrossRef
  • Oxidative stress and DNA damage in critically ill patients with sepsis
    Olgica Mihaljevic, Snezana Zivancevic-Simonovic, Danijela Jovanovic, Svetlana Miletic Drakulic, Jovana Tubic Vukajlovic, Aleksandra Markovic, Marijana Stanojevic Pirkovic, Ivan Srejovic, Vladimir Jakovljevic, Olivera Milosevic-Djordjevic
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis.2023; 889: 503655.     CrossRef
  • A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review
    Mahdi Vajdi, Pouria Sefidmooye Azar, Ata Mahmoodpoor, Farzaneh Dashti, Sarvin Sanaie, Fateme Kiani Chalmardi, Arash Karimi
    Phytotherapy Research.2023; 37(9): 3780.     CrossRef
  • Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction
    Yongjun Wei, Ping Xiao, Benjuan Wu, Fuxi Chen, Xiaofeng Shi
    Open Life Sciences.2023;[Epub]     CrossRef
  • Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation
    Xiaohui Shi, Xinwei Lv, Dong Xiao
    Clinical and Translational Science.2023; 16(11): 2189.     CrossRef
  • The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis
    George Briassoulis, Panagiotis Briassoulis, Stavroula Ilia, Marianna Miliaraki, Efrossini Briassouli
    Antioxidants.2023; 12(11): 1942.     CrossRef
  • Understanding Post-Sepsis Syndrome: How Can Clinicians Help?
    Elisabeth C van der Slikke, Lise FE Beumeler, Madlene Holmqvist, Adam Linder, Robert T Mankowski, Hjalmar R Bouma
    Infection and Drug Resistance.2023; Volume 16: 6493.     CrossRef
  • Inflammation-responsive drug delivery nanosystems for treatment of bacterial-induced sepsis
    Vincent O. Nyandoro, Calvin A. Omolo, Eman A. Ismail, Liu Yong, Thirumala Govender
    International Journal of Pharmaceutics.2023; 644: 123346.     CrossRef
  • Restoring the infected powerhouse: Mitochondrial quality control in sepsis
    F.M. Lira Chavez, L.P. Gartzke, F.E. van Beuningen, S.E. Wink, R.H. Henning, G. Krenning, H.R. Bouma
    Redox Biology.2023; 68: 102968.     CrossRef
  • Polymeric Particle BAM15 Targeting Macrophages Attenuates the Severity of LPS-Induced Sepsis: A Proof of Concept for Specific Immune Cell-Targeted Therapy
    Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Wilasinee Saisorn, Chonnavee Manipuntee, Kittawat Plengplang, Samarch Sittichaitaweekul, Panisa Jenphatanapong, Suwasin Udomkarnjananun, Warerat Kaewduangduen, Kasirapat Ariya-anandech, Amanee Samaeng, N
    Pharmaceutics.2023; 15(12): 2695.     CrossRef
  • Impact of norepinephrine on immunity and oxidative metabolism in sepsis
    Joby Thoppil, Prayag Mehta, Brett Bartels, Drashya Sharma, J. David Farrar
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial
    Abbas Taher, Farnaz Shokoohmand, Elham Abdoli, Younes Mohammadi, Maryam Mehrpooya
    Irish Journal of Medical Science (1971 -).2022; 191(4): 1913.     CrossRef
  • Biomarker Analysis for Combination Therapy of Vitamin C and Thiamine in Septic Shock: A Post-Hoc Study of the ATESS Trial
    Jong Eun Park, You Hwan Jo, Sung Yeon Hwang, Won Young Kim, Seung Mok Ryoo, Dong-Hyun Jang, Taegyun Kim, Youn-Jung Kim, Seonwoo Kim, Hyun Cho, Gun Tak Lee, Sung Phil Chung, Sung-Hyuk Choi, Tae Gun Shin, Gil Joon Suh
    Shock.2022; 57(1): 81.     CrossRef
  • Anagliptin prevents lipopolysaccharide (LPS)- induced inflammation and activation of macrophages
    Fangfang Yu, Wenxia Tian, Jie Dong
    International Immunopharmacology.2022; 104: 108514.     CrossRef
  • Pink1/Parkin-Mediated Mitophagy Regulated the Apoptosis of Dendritic Cells in Sepsis
    Yaolu Zhang, Longwang Chen, Yinan Luo, Kang Wang, Xinyong Liu, Zhong Xiao, Guangju Zhao, Yongming Yao, Zhongqiu Lu
    Inflammation.2022; 45(3): 1374.     CrossRef
  • Inhibition of mitoNEET attenuates LPS-induced inflammation and oxidative stress
    Seunghee Lee, Byeong Geun Seok, Seon-Jin Lee, Su Wol Chung
    Cell Death & Disease.2022;[Epub]     CrossRef
  • An update in the utilization of N-acetyl cysteine & vitamin c for tackling the oxidative stress in acute kidney injury secondary to robust sepsis - A systematic review
    Kaur Kulvinder Kochar, Allahbadia Gautam, Singh Mandeep
    Journal of Clinical Nephrology.2022; 6(1): 001.     CrossRef
  • Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia
    Sahebgowda Sidramagowda Patil, Ramani Soundararajan, Jutaro Fukumoto, Mason Breitzig, Helena Hernández-Cuervo, Matthew Alleyn, Muling Lin, Venkata Ramireddy Narala, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route
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    Journal of Molecular Neuroscience.2022; 72(6): 1166.     CrossRef
  • Low-power infrared laser modulates mRNA levels from genes of base excision repair and genomic stabilization in heart tissue from an experimental model of acute lung injury
    Larissa Alexsandra da Silva Neto Trajano, Luiz Philippe da Silva Sergio, Diego Sá Leal de Oliveira, Eduardo Tavares Lima Trajano, Marco Aurélio dos Santos Silva, Flávia de Paoli, André Luiz Mencalha, Adenilson de Souza da Fonseca
    Photochemical & Photobiological Sciences.2022; 21(7): 1299.     CrossRef
  • Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis
    Geng Lu, Jiawei Zhou, Ting Yang, Jin Li, Xinrui Jiang, Wenjun Zhang, Shuangshuang Gu, Jun Wang
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status
    Arash Karimi, Fatemeh Naeini, Hamid Reza Niazkar, Helda Tutunchi, Vali Musazadeh, Ata Mahmoodpoor, Vahid Asghariazar, Majid Mobasseri, Ali Tarighat-Esfanjani
    Food & Function.2022; 13(12): 6596.     CrossRef
  • An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach
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    Canadian Journal of Infectious Diseases and Medical Microbiology.2022; 2022: 1.     CrossRef
  • p66Shc in Cardiovascular Pathology
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    Cells.2022; 11(11): 1855.     CrossRef
  • Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice
    Jingshu Chen, Shu Tang, Sui Ke, James J. Cai, Daniel Osorio, Andrei Golovko, Benjamin Morpurgo, Shaodong Guo, Yuxiang Sun, Melanie Winkle, George A. Calin, Yanan Tian
    Redox Biology.2022; 54: 102377.     CrossRef
  • Comparison enteral superoxide dismutase 1 IU and 5 IU from Cucumis melo L.C extract combined with gliadin as an antioxidant and anti-inflammatory in LPS-Induced sepsis model rats
    Cut Meliza Zainumi, Gontar Alamsyah Siregar, Dadik Wahyu Wijaya, Muhammad Ichwan
    Heliyon.2022; 8(8): e10236.     CrossRef
  • Evidence-based updates to the 2021 Surviving Sepsis Campaign guidelines
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    The Nurse Practitioner.2022; 47(11): 24.     CrossRef
  • Stimuli-responsive and biomimetic delivery systems for sepsis and related complications
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    Journal of Controlled Release.2022; 352: 1048.     CrossRef
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    Journal of Cardiovascular Development and Disease.2022; 9(11): 385.     CrossRef
  • Low dimensional nanomaterials for treating acute kidney injury
    Yuanpeng Nie, Liying Wang, Xinru You, Xiaohua Wang, Jun Wu, Zhihua Zheng
    Journal of Nanobiotechnology.2022;[Epub]     CrossRef
  • Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis in mice
    Mohamed A Alblihed
    Human & Experimental Toxicology.2021; 40(2): 342.     CrossRef
  • Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology
    Amit Pant, Irene Mackraj, Thirumala Govender
    Journal of Biomedical Science.2021;[Epub]     CrossRef
  • Targeting the TXNIP‐NLRP3 interaction with PSSM1443 to suppress inflammation in sepsis‐induced myocardial dysfunction
    Linhua Wang, Hongsheng Zhao, Huifen Xu, Xiangxin Liu, Xinlong Chen, Qingyun Peng, Mingbing Xiao
    Journal of Cellular Physiology.2021; 236(6): 4625.     CrossRef
  • Mitochondrial gene mutations in pediatric septic shock
    Junsung Park, Eunju Kang, Seoon Kang, Deokhoon Kim, Dahyun Kim, Seong Jong Park, Won Kyoung Jhang
    Pediatric Research.2021; 90(5): 1016.     CrossRef
  • Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders
    Jiwon Yeo, Junseok Lee, Sanggi Lee, Won Jong Kim
    Advanced Therapeutics.2021;[Epub]     CrossRef
  • Pathophysiology of sepsis
    Pietro Arina, Mervyn Singer
    Current Opinion in Anaesthesiology.2021; 34(2): 77.     CrossRef
  • Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation
    Jérémie Joffre, Judith Hellman
    Antioxidants & Redox Signaling.2021; 35(15): 1291.     CrossRef
  • The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19
    Yu. Р. Orlov, V. V. Afanasyev, I. A. Khilenko
    Antibiotics and Chemotherapy.2021; 66(1-2): 65.     CrossRef
  • On the Possibility of Using Succinate in Hypoxia Developing in COVID-19
    Yu. P. Orlov, N. V. Govorova, O. V. Korpacheva, V. V. Afanasyev, I. A. Khilenko
    General Reanimatology.2021; 17(3): 78.     CrossRef
  • Sepsis: Evidence-based pathogenesis and treatment
    Jay Pravda
    World Journal of Critical Care Medicine.2021; 10(4): 66.     CrossRef
  • Albumin Oxidation Status in Sepsis Patients Treated With Albumin or Crystalloids
    Matteo Bonifazi, Jennifer Meessen, Alba Pérez, Francesco Vasques, Mattia Busana, Francesco Vassalli, Deborah Novelli, Roberto Bernasconi, Chiara Signori, Serge Masson, Federica Romitti, Lorenzo Giosa, Matteo Macrì, Iacopo Pasticci, Maria Michela Palumbo,
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
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    Antioxidants.2021; 10(9): 1341.     CrossRef
  • Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice
    Connie P. C. Ow, Anton Trask-Marino, Ashenafi H. Betrie, Roger G. Evans, Clive N. May, Yugeesh R. Lankadeva
    Journal of Clinical Medicine.2021; 10(17): 3798.     CrossRef
  • The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats
    Siniša Đurašević, Aleksandra Ružičić, Iva Lakić, Tomislav Tosti, Saša Đurović, Sofija Glumac, Slađan Pavlović, Slavica Borković-Mitić, Ilijana Grigorov, Sanja Stanković, Nebojša Jasnić, Jelena Đorđević, Zoran Todorović
    International Journal of Molecular Sciences.2021; 22(18): 9698.     CrossRef
  • TRP Channels as Sensors of Aldehyde and Oxidative Stress
    Katharina E. M. Hellenthal, Laura Brabenec, Eric R. Gross, Nana-Maria Wagner
    Biomolecules.2021; 11(10): 1401.     CrossRef
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    Anita Sapoznikov, Yoav Gal, Yentl Evgy, Moshe Aftalion, Shahaf Katalan, Tamar Sabo, Chanoch Kronman, Reut Falach
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  • LBP Protects Hepatocyte Mitochondrial Function Via the PPAR-CYP4A2 Signaling Pathway in a Rat Sepsis Model
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    Shock.2021; 56(6): 1066.     CrossRef
  • Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
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    Ni Yang, Li Zhang, Junhua Lv, Zequn Niu, Jie Liu, Ping Li, Zhengliang Zhang
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Immunomodulatory Effect of Doxycycline Ameliorates Systemic and Pulmonary Inflammation in a Murine Polymicrobial Sepsis Model
    Anasuya Patel, Hemant Khande, Hariharan Periasamy, Santosh Mokale
    Inflammation.2020; 43(3): 1035.     CrossRef
  • Agaricus brasiliensis Mushroom Protects Against Sepsis by Alleviating Oxidative and Inflammatory Response
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    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression
    Jesús Beltrán-García, Rebeca Osca-Verdegal, Federico V. Pallardó, José Ferreres, María Rodríguez, Sandra Mulet, Fabian Sanchis-Gomar, Nieves Carbonell, José Luis García-Giménez
    Antioxidants.2020; 9(10): 936.     CrossRef
  • Molecular mechanisms of organ damage in sepsis: an overview
    Grażyna Sygitowicz, Dariusz Sitkiewicz
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  • Mitochondrial dysfunction in critical illness during acute metabolic stress and convalescence: consequences for nutrition therapy
    Hanneke Pierre Franciscus Xaverius Moonen, Arthur Raymond Hubert Van Zanten
    Current Opinion in Critical Care.2020; 26(4): 346.     CrossRef
  • Azithromycin in Combination with Ceftriaxone Reduces Systemic Inflammation and Provides Survival Benefit in a Murine Model of Polymicrobial Sepsis
    Anasuya Patel, Jiji Joseph, Hariharan Periasamy, Santosh Mokale
    Antimicrobial Agents and Chemotherapy.2018;[Epub]     CrossRef

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